Description
LRP1B is a putative tumor suppressor and a member of the low-density lipoprotein (LDL) receptor family. The LDL receptor family have roles related to clearance of extracellular ligand and are proposed to be involved in extracellular signal transduction. silencing and down-expression of LRP1B as been observed in renal cell carcinoma and thyroid cancer. Further Deletion of LRP1B has been associated with chemotherapy resistance in high-grade serous cancers.
Cyan = gene · Slate = variant · Green = drug · Click variant to filter table
Variants (3)
| CIViC ID | Name | HGVS | Type(s) |
|---|---|---|---|
| 647 | Deletion | transcript_ablation | |
| 266 | Exon 12-22 Deletion | ENST00000389484.3:c.1790_3520del | exon_loss_variant |
| 5081 | Loss-of-function |