Description
CDK4, along with its partner CDK6, are key players in cell cycle progression. The complex has been implicated in a number of cancer types, and is the focus of therapeutic research and development. One targeted therapy for CDK inhibition is palbociclib, which may slow the growth of advanced stage breast cancers. It has also been shown, in mouse, that CDK inhibition may sensitize mutant PIK3CA tumors to PI3K inhibitors.
Cyan = gene · Slate = variant · Green = drug · Click variant to filter table
Variants (3)
| CIViC ID | Name | HGVS | Type(s) |
|---|---|---|---|
| 553 | Amplification | transcript_amplification | |
| 25 | EXPRESSION | ||
| 556 | R24C ARG24CYS,RS11547328 | NM_000075.3:c.70C>T,NP_000066.1:p.Arg24Cys,ENST00000257904.6:c.70C>T,NC_000012.11:g.58145431G>A | missense_variant |