Description
MAP2K1 is a dual-specificity kinase known for it's involvement in the ERK pathway by activation of ERK1 and ERK2. MAP2K1 activating mutations have been observed in a number of cancers including ovarian, melanoma and lung. These activating mutations are generally found in the N-terminal negative regulatory region or the ATP-binding region of the N-terminal lobe. Inhibitors of MEK genes have been shown to inhibit tumor growth in these cases.
Cyan = gene · Slate = variant · Green = drug · Click variant to filter table
Variants (5)
| CIViC ID | Name | HGVS | Type(s) |
|---|---|---|---|
| 627 | C121S CYS121SER | ENST00000307102.5:c.362G>C,NC_000015.9:g.66729154G>C,NM_002755.3:c.362G>C,NP_002746.1:p.Cys121Ser | missense_variant |
| 1272 | K57N LYS57ASN,RS869025608 | NM_002755.3:c.171G>T,NP_002746.1:p.Lys57Asn,NG_008305.1:g.53245G>T,NC_000015.9:g.66727455G>T,ENST00000307102.5:c.171G>T | missense_variant |
| 82 | P124S PRO124SER | ENST00000307102.5:c.370C>T,NC_000015.9:g.66729162C>T,NM_002755.3:c.370C>T,NP_002746.1:p.Pro124Ser | missense_variant |
| 83 | Q56P GLN56PRO,RS1057519729 | ENST00000307102.5:c.167A>C,NC_000015.9:g.66727451A>C,NM_002755.3:c.167A>C,NP_002746.1:p.Gln56Pro | missense_variant |
| 655 | Q56_V60del | ENST00000307102.5:c.165_179del,NC_000015.9:g.66727449_66727463del | inframe_deletion |