CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/R367Q

R367Q

CIViC ID: 238 · Gene: NT5C2

Variant Summary

Also known as
ARG367GLN
HGVS
NC_000010.10:g.104852955C>T
Variant Type(s)
missense_variant
Evidence Items
5

Evidence Level Distribution

Level C: 1Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = NT5C2 and variant = R367Q.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsResistanceT-cell Acute Lymphoblastic LeukemiaThioguanine,Mercaptopurine4
DPredictiveDoes Not SupportResistanceT-cell Acute Lymphoblastic LeukemiaNelarabine,Arabinosylguanine4
DPredictiveDoes Not SupportResistanceChildhood Acute Lymphocytic LeukemiaPrednisolone,Doxorubicin,Cytarabine,Gemcitabine4
DPredictiveSupportsResistanceChildhood Acute Lymphocytic LeukemiaThioguanine,Mercaptopurine4
CPredictiveSupportsResistanceChildhood Acute Lymphocytic LeukemiaThioguanine,Mercaptopurine2