Description
This gene, when mutated to be over-active, has been linked to chemotherapy resistance in relapsed T-cell Acute Lymphoblastic Leukemia.
Cyan = gene · Slate = variant · Green = drug · Click variant to filter table
Variants (6)
| CIViC ID | Name | HGVS | Type(s) |
|---|---|---|---|
| 240 | D407A ASP407ALA | NC_000010.10:g.104850745T>G,NM_012229.4:c.1220A>C,NP_036361.1:p.Asp407Ala,ENST00000343289.5:c.1220A>C | missense_variant |
| 239 | K359Q LYS359GLN | NC_000010.10:g.104852980T>G,NM_012229.4:c.1075A>C,NP_036361.1:p.Lys359Gln,ENST00000343289.5:c.1075A>C | missense_variant |
| 2898 | Mutation | ||
| 2896 | R238W | ||
| 238 | R367Q ARG367GLN | NC_000010.10:g.104852955C>T | missense_variant |
| 2897 | S445F | gain_of_function_variant,missense_variant |