CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/S445F

S445F

CIViC ID: 2897 · Gene: NT5C2

Variant Summary

HGVS
—
Variant Type(s)
gain_of_function_variant,missense_variant
Evidence Items
3

Evidence Level Distribution

Level C: 1Level D: 2

Evidence Items

Showing CIViC evidence rows where gene = NT5C2 and variant = S445F.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsResistanceChildhood Acute Lymphocytic LeukemiaThioguanine,Mercaptopurine4
DPredictiveDoes Not SupportResistanceChildhood Acute Lymphocytic LeukemiaPrednisolone,Doxorubicin,Gemcitabine,Cytarabine4
CPrognosticSupportsPoor OutcomeChildhood Acute Lymphocytic Leukemia2