Variant Summary
- Also known as
- GLU17LYS,RS34409589
- HGVS
- NC_000014.8:g.105246551C>T,NM_001014432.1:c.49G>A,NP_001014432.1:p.Glu17Lys,ENST00000407796.2:c.49G>A
- Variant Type(s)
- missense_variant
- Evidence Items
- 5
Evidence Level Distribution
Level B: 1Level C: 1Level D: 3
Evidence Items
Showing CIViC evidence rows where gene = AKT1 and variant = E17K.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Predictive | Supports | Sensitivity/Response | Cancer | Capivasertib | 4 |
| D | Predictive | Does Not Support | Sensitivity/Response | Breast Cancer | Akt Inhibitor MK2206 | 3 |
| C | Predictive | Supports | Sensitivity/Response | Breast Cancer | Capivasertib | 3 |
| D | Predictive | Supports | Sensitivity/Response | Melanoma | Uprosertib | 2 |
| D | Predictive | Supports | Resistance | Melanoma | Vemurafenib | 1 |