Description
AKT1, also referred to as protein kinase B, is a known oncogene. AKT activation relies on the PI3K pathway, and is recognized as a critical node in the pathway. The E17 hotspot is the most characterized of AKT1 mutations, and has been shown to result in activation of the protein. Mutations in AKT1 have also been shown to confer resistance to allosteric kinase inhibitors in vitro.
Cyan = gene · Slate = variant · Green = drug · Click variant to filter table
Variants (5)
| CIViC ID | Name | HGVS | Type(s) |
|---|---|---|---|
| 4 | E17K GLU17LYS,RS34409589 | NC_000014.8:g.105246551C>T,NM_001014432.1:c.49G>A,NP_001014432.1:p.Glu17Lys,ENST00000407796.2:c.49G>A | missense_variant |
| 4906 | Mutation | ||
| 2360 | Overexpression | ||
| 169 | Q79K Q17K,GLN79LYS,RS1057519804 | NC_000014.8:g.105243048G>T,NM_001014432.1:c.235C>A,NP_001014432.1:p.Gln79Lys,ENST00000407796.2:c.235C>A | missense_variant |
| 3257 | S473 Phosphorylation |