CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/I1171

I1171

CIViC ID: 527 · Gene: ALK

Variant Summary

Also known as
ILE1171
HGVS
ENST00000389048.3:c.3512T>C,NC_000002.11:g.29445213A>G,NM_004304.4:c.3512T>C,NP_004295.2:p.Ile1171Thr
Variant Type(s)
missense_variant
Evidence Items
7

Evidence Level Distribution

Level C: 4Level D: 3

Evidence Items

Showing CIViC evidence rows where gene = ALK and variant = I1171.

LevelTypeDirectionSignificanceDiseaseDrugsRating
CPredictiveSupportsResistanceLung Non-small Cell CarcinomaAlectinib4
CPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaCeritinib4
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaCeritinib4
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaALK Inhibitor TAE6843
DPredictiveSupportsResistanceLung Non-small Cell CarcinomaCrizotinib3
CPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaCeritinib3
CPredictiveSupportsResistanceLung Non-small Cell CarcinomaAlectinib2