ALK amplifications, fusions and mutations have been shown to be driving events in non-small cell lung cancer. While crizontinib has demonstrated efficacy in treating the amplification, mutations in ALK have been shown to confer resistance to current tyrosine kinase inhibitors. Second-generation TKI's have seen varied success in treating these resistant cases, and the HSP90 inhibitor 17-AAG has been shown to be cytostatic in ALK-altered cell lines.
Cyan = gene · Slate = variant · Green = drug · Click variant to filter table
| CIViC ID | Name | HGVS | Type(s) |
|---|---|---|---|
| 839 | Alternative Transcript (ATI) ALK(ATI),ALK INTRON 19 ATI ISOFORM,ALK ALTERNATIVE ISOFORM | ||
| 4301 | Amplification | ||
| 4331 | C1156Y RS1057519859,CYS1156TYR | ENST00000389048.3:c.3467G>A,NC_000002.11:g.29445258C>T,NM_004304.4:c.3467G>A,NP_004295.2:p.Cys1156Tyr | missense_variant |
| 5171 | Exon 2-18 Deletion | ||
| 550 | Exon 4-11 Deletion | NM_004304.5:c.953_2041del,NP_004295.2:p.Gly318_Val681delinsVal,NC_000002.11:g.29474528_29853656del | inframe_deletion |
| 8 | F1174L PHE1174LEU,RS863225281 | NM_004304.4:c.3522C>A,NP_004295.2:p.Phe1174Leu,NC_000002.11:g.29443695G>T,ENST00000389048.3:c.3522C>A | missense_variant |
| 549 | F1245C PHE1245CYS,RS863225283 | NM_004304.4:c.3734T>G,NP_004295.2:p.Phe1245Cys,NC_000002.11:g.29436859A>C,ENST00000389048.3:c.3734T>G | missense_variant |
| 1295 | F1245V PHE1245VAL,RS281864720 | NM_004304.4:c.3733T>G,NP_004295.2:p.Phe1245Val,NC_000002.11:g.29436860A>C,ENST00000389048.3:c.3733T>G | missense_variant |
| 171 | G1202R RS1057519783 | ENST00000389048.3:c.3604G>A,NC_000002.11:g.29443613C>T,NM_004304.4:c.3604G>A,NP_004295.2:p.Gly1202Arg | missense_variant |
| 308 | G1269A RS1057519781 | ENST00000389048.3:c.3806G>C,NC_000002.11:g.29432682C>G,NM_004304.4:c.3806G>C,NP_004295.2:p.Gly1269Ala | missense_variant |
| 527 | I1171 ILE1171 | ENST00000389048.3:c.3512T>C,NC_000002.11:g.29445213A>G,NM_004304.4:c.3512T>C,NP_004295.2:p.Ile1171Thr | missense_variant |
| 588 | I1171N RS1057519698 | ENST00000389048.3:c.3512T>A,NC_000002.11:g.29445213A>T,NM_004304.4:c.3512T>A,NP_004295.2:p.Ile1171Asn | missense_variant |
| 589 | I1171S ILE1171SER | ENST00000389048.3:c.3512T>G,NC_000002.11:g.29445213A>C | missense_variant |
| 3371 | I1171T | ||
| 307 | L1152R RS1057519785,LEU1152ARG | ENST00000389048.3:c.3455T>G,NC_000002.11:g.29445270A>C,NM_004304.4:c.3455T>G,NP_004295.2:p.Leu1152Arg | missense_variant |
| 4324 | L1196M LEU1196MET | missense_variant | |
| 1275 | L1198F LEU1198PHE,RS751306825 | ENST00000389048.3:c.3592C>T,NC_000002.11:g.29443625G>A,NM_004304.4:c.3592C>T,NP_004295.2:p.Leu1198Phe | missense_variant |
| 512 | Mutation | gene_variant,gain_of_function_variant | |
| 9 | R1275Q ARG1275GLN,RS113994087 | NM_004304.4:c.3824G>A,NP_004295.2:p.Arg1275Gln,NC_000002.11:g.29432664C>T,ENST00000389048.3:c.3824G>A | missense_variant |
| 172 | S1206Y RS1057519782 | ENST00000389048.3:c.3617C>A,NC_000002.11:g.29443600G>T,NM_004304.4:c.3617C>A,NP_004295.2:p.Ser1206Tyr | missense_variant |
| 4389 | T1151dup T1151_L1152INST | NC_000002.11:g.29445271_29445272insCGT | inframe_insertion |
| 528 | V1180L | ENST00000389048.3:c.3538G>C,NC_000002.11:g.29443679C>G,NP_004295.2:p.Val1180Leu,NM_004304.5:c.3538G>C | missense_variant |