CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/R1275Q

R1275Q

CIViC ID: 9 · Gene: ALK

Variant Summary

Also known as
ARG1275GLN,RS113994087
HGVS
NM_004304.4:c.3824G>A,NP_004295.2:p.Arg1275Gln,NC_000002.11:g.29432664C>T,ENST00000389048.3:c.3824G>A
Variant Type(s)
missense_variant
Evidence Items
6

Evidence Level Distribution

Level C: 2Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = ALK and variant = R1275Q.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseNeuroblastomaLorlatinib4
DPredictiveSupportsSensitivity/ResponseNeuroblastomaCrizotinib3
DPredictiveSupportsResistanceNeuroblastomaALK Inhibitor TAE6843
CPredictiveSupportsSensitivity/ResponseNeuroblastomaCrizotinib2
CPredictiveSupportsSensitivity/ResponseNeuroblastomaCrizotinib2
DPredictiveSupportsSensitivity/ResponseCancerALK Inhibitor TAE6842