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EGFR exon 20 insertion — resistance to standard EGFR TKIs

Gene: EGFR · Type: mutation

Indications: Non-small cell lung cancer

Sensitivity Resistance CIViC Context

Linked CIViC Profile: EGFR EXON 20 INSERTION

Evidence Level Distribution

Level A: 4Level B: 2Level C: 1

Level	Type	Direction	Significance	Disease	Drugs	Rating
A	Predictive	Supports	Sensitivity/Response	Lung Non-small Cell Carcinoma	Amivantamab	4
A	Predictive	Supports	Sensitivity/Response	Lung Non-small Cell Carcinoma	Mobocertinib	4
A	Predictive	Supports	Sensitivity/Response	Lung Non-small Cell Carcinoma	Amivantamab,Chemotherapy	4
A	Predictive	Supports	Sensitivity/Response	Lung Non-small Cell Carcinoma	Sunvozertinib	4
B	Predictive	Supports	Resistance	Lung Adenocarcinoma	Afatinib	3
B	Predictive	Supports	Sensitivity/Response	Lung Non-small Cell Carcinoma	Osimertinib	2
C	Predictive	Supports	Resistance	Lung Adenocarcinoma	Erlotinib	0