CIViC
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Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
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Biomarker
EGFR exon 20 insertion — resistance to standard EGFR TKIs
Gene:
EGFR
· Type:
mutation
Indications: Non-small cell lung cancer
Sensitivity
Resistance
CIViC Context
FDA Resistance Assertions
Drug
Indication
Recommendation
FDA Source
Link
Erlotinib
Non-small cell lung cancer
NOT RECOMMENDED
FDA Label
Label
Gefitinib
Non-small cell lung cancer
NOT RECOMMENDED
FDA Label
Label
Afatinib
Non-small cell lung cancer
NOT RECOMMENDED
FDA Label
Label
Osimertinib
Non-small cell lung cancer
NOT RECOMMENDED
FDA Label
Label