CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Variants

1951 variants indexed

Variant Types

Sequence Ontology (SO) terms describing the molecular consequence of each variant, as curated in CIViC. Hover a bar for the definition.

CIViC IDGeneVariantHGVSType(s)
752MLH1A424T
ALA424THR,RS377433038
NM_000249.3:c.1270G>A,NP_000240.1:p.Ala424Thr,ENST00000231790.2:c.1270G>A,NC_000003.11:g.37067359G>Amissense_variant
760MLH1A681V
ALA681VAL,A440V,RS63750864
NM_000249.3:c.2042C>T,NP_000240.1:p.Ala681Val,ENST00000231790.2:c.2042C>T,NC_000003.11:g.37090447C>Tmissense_variant
746MLH1D667FS
ASP667FS
NC_000003.11:g.37090406del,ENST00000231790.2:c.2001delframeshift_truncation
725MLH1E13fs
GLU13ARGFS,RS63750081,E13FS*3
NM_000249.3:c.37delG,NP_000240.1:p.Glu13Argfs,ENST00000231790.2:c.37delG,NC_000003.11:g.37035075delframeshift_truncation,minus_1_frameshift_variant
662MLH1EXPRESSION
730MLH1G606FS*2
GLY606FS
ENST00000231790.2:c.1816_1817delGG,NC_000003.11:g.37089094_37089095delframeshift_truncation
759MLH1G65D
GLY65ASP,RS63751465
NM_000249.3:c.194G>A,NP_000240.1:p.Gly65Asp,ENST00000231790.2:c.194G>A,NC_000003.11:g.37038187G>Amissense_variant
757MLH1G67R
GLY67ARG,RS63750206
NC_000003.11:g.37038192G>A,NP_000240.1:p.Gly67Arg,ENST00000231790.2:c.199G>A,NM_000249.3:c.199G>Amissense_variant
758MLH1I68S
ILE68SER
ENST00000231790.2:c.203T>G,NC_000003.11:g.37038196T>Gmissense_variant
733MLH1K618DEL
RS63751247,LYS618DEL
NC_000003.11:g.37089130_37089132del,ENST00000231790.2:c.1852_1854delAAG,NM_000249.3:c.1852_1854delAAG,NP_000240.1:p.Lys618delinframe_deletion
4641MLH1Loss
747MLH1M1L
MET1LEU
NC_000003.11:g.37035039A>T,ENST00000231790.2:c.1A>Tmissense_variant
769MLH1M490T
MET490THR
ENST00000231790.2:c.1469T>C,NC_000003.11:g.37070334T>Cmissense_variant
538MLH1METHYLATION
751MLH1N551T
ASN551THR,RS63750271
NM_000249.3:c.1652A>C,NP_000240.1:p.Asn551Thr,ENST00000231790.2:c.1652A>C,NC_000003.11:g.37081770A>Cmissense_variant
756MLH1P536FS
PRO536FS
NC_000003.11:g.37081726del,ENST00000231790.2:c.1608delframeshift_truncation
753MLH1Q149*
Q149X,GLN149TER,RS63751302
NM_000249.3:c.445C>T,NP_000240.1:p.Gln149Ter,ENST00000231790.2:c.445C>T,NC_000003.11:g.37048546C>Tstop_gained
744MLH1Q426FS
GLN426FS
ENST00000231790.2:c.1276delC,NC_000003.11:g.37067365delframeshift_truncation
741MLH1R100*
ARG100TER,R100X,RS63751221
NM_000249.3:c.298C>T,NP_000240.1:p.Arg100Ter,ENST00000231790.2:c.298C>T,NC_000003.11:g.37042536C>Tstop_gained
754MLH1R226*
R226X,ARG226TER,R128*,RS63751615
NM_000249.3:c.676C>T,NP_000240.1:p.Arg226Ter,ENST00000231790.2:c.676C>T,NC_000003.11:g.37053589C>Tstop_gained
749MLH1R265G
ARG265GLY
ENST00000231790.2:c.793C>G,NC_000003.11:g.37058999C>Gmissense_variant
735MLH1R687FS
ARG687GLYFS,RS863225381
NM_000249.3:c.2059delC,NP_000240.1:p.Arg687Glyfs,ENST00000231790.2:c.2059delC,NC_000003.11:g.37090464delframeshift_variant
743MLH1T117M
THR117MET,RS63750781
NM_000249.3:c.350C>T,NP_000240.1:p.Thr117Met,ENST00000231790.2:c.350C>T,NC_000003.11:g.37045935C>Tmissense_variant
750MLH1V213FS
VAL213FS
ENST00000231790.2:c.638delT,NC_000003.11:g.37053551delframeshift_truncation
745MLH1V49A
VAL49ALA
ENST00000231790.2:c.146T>C,NC_000003.11:g.37038139T>Cmissense_variant
728MLH1V534R
VAL534ARG
ENST00000231790.2:c.1600_1601delinsAG,NC_000003.11:g.37081718_37081719delinsAGmissense_variant
731MLH1c.790+1G>A
RS267607789
NM_000249.3:c.790+1G>A,NC_000003.11:g.37056036G>A,ENST00000231790.2:c.790+1G>Asplice_donor_variant
5262MMP1Overexpression
487MMP2SERUM LEVELS
488MMP9SERUM LEVELS
4993MN1Rearrangement
4995MN1::BEND2Fusion
MN1-BEND2
transcript_fusion
4535MN1::ZFTAFusion
MN1-ZFTA
transcript_fusion
4999MNX1::ETV6Fusion
MNX1-ETV6
transcript_fusion
428MRE11Frameshiftframeshift_variant
370MRE11Lossloss_of_function_variant
4018MS4A1Mutation
763MSH2E28FSNC_000002.11:g.47630414dupGframeshift_elongation
773MSH2E483G
GLU483GLY
NC_000002.11:g.47690231A>G,ENST00000233146.2:c.1448A>Gmissense_variant
770MSH2K172*
K172X,LYS172TER
ENST00000233146.2:c.514A>T,NC_000002.11:g.47637380A>Tstop_gained
808MSH2Lossloss_of_function_variant
727MSH2R383*
R383X,ARG383TER,RS63749849
NM_000251.2:c.1147C>T,NP_000242.1:p.Arg383Ter,ENST00000233146.2:c.1147C>T,NC_000002.11:g.47656951C>Tstop_gained
762MSH2V273FSENST00000233146.2:c.818delT,NC_000002.11:g.47641433delframeshift_variant
765MSH6I891FS
ILE891FS
ENST00000234420.5:c.2672_2673delTC,NC_000002.11:g.48027794_48027795delframeshift_truncation
809MSH6LOSSloss_of_function_variant
761MSH6P138T
PRO138THR
ENST00000234420.5:c.412C>A,NC_000002.11:g.48018217C>Amissense_variant
776MSH6R1242C
ARG1242CYS,RS587779285
NM_000179.2:c.3724C>T,NP_000170.1:p.Arg1242Cys,ENST00000234420.5:c.3724C>T,NC_000002.11:g.48033420C>Tmissense_variant
767MSH6R1242H
ARG1242HIS,RS63750119
NM_000179.2:c.3725G>A,NP_000170.1:p.Arg1242His,ENST00000234420.5:c.3725G>A,NC_000002.11:g.48033421G>Amissense_variant
775MSH6V352I
VAL352ILE,RS730881787
NM_000179.2:c.1054G>A,NP_000170.1:p.Val352Ile,ENST00000234420.5:c.1054G>A,NC_000002.11:g.48026176G>Amissense_variant
4944MSIHigh
MSI-H,Microsatellite Instability High,deficient DNA mismatch repair,dMMR