CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Variants

1951 variants indexed

Variant Types

Sequence Ontology (SO) terms describing the molecular consequence of each variant, as curated in CIViC. Hover a bar for the definition.

CIViC IDGeneVariantHGVSType(s)
2235RASA1Loss-of-function
537RB1EXPRESSION
606RB1Loss-of-functionloss_of_function_variant
638RB1M695FS*26ENST00000267163.4:c.2083_2084insA,NC_000013.10:g.49033946_49033947insAframeshift_truncation
799RB1Mutationgene_variant
547RB1Overexpression
632RB1PHOSPHORYLATION
4647RB1Wildtype
3116RBM15::MRTFAFusion
RBM15-MKL1,RBM15-MRTFA,OTT-MAL
transcript_fusion
2681RCSD1::ABL1Fusion
RCSD1-ABL1
transcript_fusion
3526RCSD1::ABL2Fusion
RCSD1-ABL2
transcript_fusion
154RELAMPLIFICATIONtranscript_amplification
1260RETC609Y
CYS609TYR
NM_020630.4:c.1826G>A,NC_000010.10:g.43609070G>A,NP_065681.1:p.Cys609Tyr,ENST00000355710.3:c.1826G>Amissense_variant
1700RETC634R
112RETC634W
CYS634TRP
NM_020975.4:c.1902C>G,NP_065681.1:p.Cys634Trp,ENST00000355710.3:c.1902C>G,NC_000010.10:g.43609950C>Gmissense_variant
4785RETE632_L633delENST00000355710.8:c.1894_1899del ,ENSP00000347942.3:p.Glu632_Leu633del ,NM_020975.6:c.1894_1899del ,NP_066124.1:p.Glu632_Leu633deldeletion
3226RETG810C
5203RETG810R
3227RETG810S
113RETM918T
MET918THR,RS74799832
NM_020975.4:c.2753T>C,NP_065681.1:p.Met918Thr,ENST00000355710.3:c.2753T>C,NC_000010.10:g.43617416T>Cmissense_variant
1690RETMutation
597RETOverexpression
2568RETV804M
2865RFX3::JAK2Fusion
RFX3-JAK2
transcript_fusion
665RHOAMUTATIONtranscription_variant,gain_of_function_variant
573RICTORAmplificationtranscript_amplification
297RIT1Mutationtranscript_variant
296RIT1OVEREXPRESSION
493ROBO4EXPRESSION
1271ROS1G2032R
GLY2032ARG,GLY2026ARG,GLY2028ARG,G2026R,G2028R,RS1057519788
NC_000006.11:g.117638347C>T,NM_002944.2:c.6094G>A,NP_002935.2:p.Gly2032Arg,ENST00000368508.3:c.6094G>A,NM_001378902.1:c.6076G>A,NP_001365831.1:p.Gly2026Arg,NP_001365820.1:p.Gly2028Arg,NM_001378891.1:c.6082G>A,NC_000006.12:g.117317184C>T,ENST00000368507.8:c.6076G>Amissense_variant
518ROS1G2101A
GLY2095ALA,G2095A,GLY2101ALA
NC_000006.11:g.117631376C>G,ENST00000368508.3:c.6302G>C,NM_002944.2:c.6302G>C,NP_002935.2:p.Gly2101Ala,ENST00000368507.8:c.6284G>C,NM_001378902.1:c.6284G>C,NP_001365831.1:p.Gly2095Alamissense_variant
516ROS1L2026M
LEU2026MET
NC_000006.11:g.117638365G>T,ENST00000368508.3:c.6076C>A,NM_002944.2:c.6076C>A,NP_002935.2:p.Leu2026Metmissense_variant
517ROS1L2155S
L2149S,LEU2155SER,LEU2149SER
NC_000006.11:g.117630062A>G,NM_002944.2:c.6464T>C,NP_002935.2:p.Leu2155Ser,ENST00000368508.3:c.6464T>C,ENSP00000357493.3:p.Leu2149Ser,NP_001365831.1:p.Leu2149Ser ,ENST00000368507.8:c.6446T>C,NM_001378902.1:c.6446T>Cmissense_variant
395RPS6PHOSPHORYLATION
795RRM1Overexpression
1257RRM1Underexpression
796RRM2OVEREXPRESSION
358RSF1Amplificationtranscript_amplification
807RUNX1A107P
A134P,ALA134PRO,RS74315451
NM_001754.4:c.400G>C,NP_001745.2:p.Ala134Pro,NC_000021.8:g.36252962C>G,ENST00000344691.4:c.400G>Cmissense_variant
806RUNX1D198Y
ASP198TYR
NC_000021.8:g.36231792C>Amissense_variant,loss_of_function_variant
802RUNX1K83E
LYS83GLU,K110E,RS121912498
NC_000021.8:g.36259163T>C,NP_001001890.1:p.Lys83Glu,NM_001001890.2:c.247A>G,ENST00000344691.4:c.247A>Gmissense_variant
155RUNX1Mutationloss_of_function_variant,transcript_variant
804RUNX1R135FSX177
810RUNX1T148HFSX9
C.442_449DEL,THR148HISFSX9,RS587776811
NM_001754.4:c.442_449delACCGCAGC,NP_001745.2:p.Thr148Hisfs,NC_000021.8:g.36252913_36252920del,ENST00000300305.3:c.442_449delACCGCAGCframeshift_truncation
803RUNX1Y260*
Y260X,TYR260TER,RS121912499
NM_001001890.2:c.780C>A,NP_001001890.1:p.Tyr260Ter,NC_000021.8:g.36171704G>T,ENST00000344691.4:c.780C>Astop_gained
3126RUNX1::RUNX1T1Fusion
RUNX1-RUNX1T1
transcript_fusion
4253SCP2::NTRK1Fusion
SCP2-NTRK1
transcript_fusion
2179SDC4::NRG1Fusion
SDC4-NRG1
transcript_fusion
5013SDC4::ROS1Fusion
SDC4-ROS1
transcript_fusion
2411SDHBp.193_196dupSTSC (c.577_588dupAGCACCAGCTGC)
C.589_600DUP
NM_003000.2:c.577_588dupAGCACCAGCTGC,NP_002991.2:p.193_196dupSTSC,NC_000001.10:g.17350522_17350533dupinframe_insertion