CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Variants

1951 variants indexed

Variant Types

Sequence Ontology (SO) terms describing the molecular consequence of each variant, as curated in CIViC. Hover a bar for the definition.

CIViC IDGeneVariantHGVSType(s)
397BRCA1Expression
131BRCA1Loss-of-functionloss_of_function_variant,loss_of_heterozygosity
185BRCA1Mutationgene_variant,loss_of_function_variant
477BRCA1P968FS
3021INSTC,PRO968LEUFS,RS398122670
NM_007294.3:c.2902_2903insTC,NP_009225.1:p.Pro968Leufs,NC_000017.10:g.41244645_41244646insGA,ENST00000471181.2:c.2902_2903insTCframeshift_truncation
1246BRCA1Q1467*
Q1467X,GLN1467TER,RS397509171
NM_007294.3:c.4399C>T,NP_009225.1:p.Gln1467Ter,NC_000017.10:g.41228590G>A,ENST00000357654.3:c.4399C>Tstop_gained
403BRCA1Underexpression
1555BRCA1W1815X
W125X,W1519X,W1550X,W1576X,W1768X,W1836X,W306X,W48X,W632X,W664X,W673X,W711X
stop_gained
661BRCA2D3095E
ASP3095GLU,RS80359198
NM_000059.3:c.9285C>A,NP_000050.2:p.Asp3095Glu,ENST00000544455.1:c.9285C>A,NC_000013.10:g.32968854C>Amissense_variant
2871BRCA2K3326*
132BRCA2Loss-of-functionloss_of_function_variant
1248BRCA2M1I
MET1ILE,RS80358650
NC_000013.10:g.32890600G>T,NM_000059.3:c.3G>T,NP_000050.2:p.Met1Ile,ENST00000544455.1:c.3G>Tmissense_variant
1247BRCA2M1R
MET1ARG,RS80358547
NM_000059.3:c.2T>G,NC_000013.10:g.32890599T>G,NP_000050.2:p.Met1Arg,ENST00000544455.1:c.2T>Gmissense_variant
186BRCA2Mutationgene_variant,loss_of_function_variant
1252BRCA2R2336P
ARG2336PRO,RS28897743
NM_000059.3:c.7007G>C,NP_000050.2:p.Arg2336Pro,NC_000013.10:g.32921033G>C,ENST00000544455.1:c.7007G>Cmissense_variant
708BRCA2TRUNCATING MUTATIONfeature_truncation
1249BRCA2V159M
VAL159MET,RS80358702
ENST00000544455.1:c.475G>A,NM_000059.3:c.475G>A,NP_000050.2:p.Val159Met,NC_000013.10:g.32900287G>Amissense_variant
1251BRCA2V211INC_000013.10:g.32900751G>Amissense_variant
1250BRCA2V211LNC_000013.10:g.32900751G>Cmissense_variant
4973BRD4::NUTM1Fusion
BRD4-NUTM1
transcript_fusion
4439BRIP1Mutation
168BTKC481S
CYS481SER,RS1057519826
NC_000023.10:g.100611165A>T,ENST00000308731.7:c.1441T>A,NM_000061.2:c.1441T>A,NP_000052.1:p.Cys481Sermissense_variant
2169BTKMUTATION
870BTKT316A
THR316ALA
ENST00000308731.7:c.946T>C,NM_000061.2:c.946T>C,NC_000023.10:g.100613633T>Cmissense_variant
5163C19MCAlterations
5157C19MCAmplification
5158C19MCTTYH1::C19MC fusion
5159C19MCv::C19MC fusion
2769CAD::ALKFusion
CAD-ALK
transcript_fusion
559CALREXON 9 FRAMESHIFTexon_variant
2388CALRMutation
650CASP8D302H
RS1045485,D285H,ASP302HIS
NM_001228.4:c.904G>C,NP_001219.2:p.Asp302His,ENST00000264275.5:c.904G>C,NC_000002.11:g.202149589G>Cmissense_variant,polymorphic_sequence_variant
346CASP8Overexpression
2630CBFA2T3::GLIS2Fusion
CBFA2T3-GLIS2
transcript_fusion
431CBFB::MYH11Fusion
INV(16)(P13.1;Q22),T(16;16)(P13.1;Q22),CBFB-MYH11
transcript_fusion
2638CBLY371H
643CBLBRS2305035
D424D
NC_000003.11:g.105439026G>A,NM_001321788.1:c.1272C>T,ENST00000264122.4:c.1272C>Tsynonymous_variant,polymorphic_sequence_variant
326CBLCEXPRESSION
626CCDC6::RETFusion
CCDC6-RET
transcript_fusion
18CCND1Amplificationtranscript_amplification
19CCND1Expression
20CCND1Overexpression
2746CCND2Amplification
21CCND2OVEREXPRESSION
22CCND2PROMOTER DEMETHYLATION
2747CCND3Amplification
23CCND3Lossloss_of_function_variant
187CCNE1Amplificationtranscript_amplification
24CCNE1Overexpression
2718CCNE1Underexpression
276CD274Expression