CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Variants

1951 variants indexed

Variant Types

Sequence Ontology (SO) terms describing the molecular consequence of each variant, as curated in CIViC. Hover a bar for the definition.

CIViC IDGeneVariantHGVSType(s)
4113TP53C124R
924TP53C135W
CYS135TRP,C3W,C96W
NM_000546.5:c.405C>G,NP_000537.3:p.Cys135Trp,NC_000017.10:g.7578525G>C,ENST00000269305.4:c.405C>Gmissense_variant
2648TP53C238Y
CYS238TYR
NC_000017.10:g.7577568C>T,NM_000546.5:c.713G>A,NP_000537.3:p.Cys238Tyr,ENST00000269305.4:c.713G>Amissense_variant
1062TP53C242F
RS121912655
NM_000546.5:c.725G>T,NP_000537.3:p.Cys242Phe,NC_000017.10:g.7577556C>A,ENST00000269305.4:c.725G>Tmissense_variant
1063TP53C242S
RS121912655
missense_variant
1064TP53C242Y
RS121912655
NM_000546.5:c.725G>A,NP_000537.3:p.Cys242Tyr,NC_000017.10:g.7577556C>T,ENST00000269305.4:c.725G>Amissense_variant
1300TP53CONSERVED DOMAIN MUT
3401TP53D259V
1044TP53D281E
ASP281GLU,D149E,D242E
NM_000546.5:c.843C>G,NP_000537.3:p.Asp281Glu,NC_000017.10:g.7577095G>C,ENST0000029305.4:c.843C>Gmissense_variant
3792TP53D281N
242TP53DNA Binding Domain MutationDNA_binding_site
221TP53Deleterious Mutation
3780TP53E224K
3772TP53E258K
1043TP53E285K
GLU285LYS
ENST00000269305.4:c.853G>Amissense_variant
915TP53E286Kmissense_variant
4106TP53E68G
1053TP53F270S
PHE270SER,F138S,F231S
NC_000017.10:g.7577129A>G,NM_000546.5:c.809T>C,NP_000537.3:p.Phe270Ser,ENST00000269305.4:c.809T>Cmissense_variant
3419TP53G154S
1060TP53G244S
GLY244SER,G112S,G205S
NM_000546.5:c.730G>A,NP_000537.3:p.Gly244Ser,NC_000017.10:g.7577551C>T,ENST00000269305.4:c.730G>Amissense_variant
1036TP53G245D
RS121912656
NC_000017.10:g.7577547C>T,NM_000546.5:c.734G>A,NP_000537.3:p.Gly245Asp,ENST00000269305.4:c.734G>Amissense_variant
879TP53G245S
RS28934575
NC_000017.10:g.7577548C>T,NM_000546.5:c.733G>A,NP_000537.3:p.Gly245Ser,ENST00000269305.4:c.733G>Amissense_variant
3773TP53G262D
3774TP53G266E
1055TP53G266Rmissense_variant
4122TP53G266V
3791TP53G279E
4112TP53H115Y
3783TP53H168Y
4103TP53H178P
1082TP53H179R
HIS179ARG,H140R,H47R
NC_000017.10:g.7578394T>C,NM_000546.5:c.536A>G,NP_000537.3:p.His179Arg,ENST00000269305.4:c.536A>Gmissense_variant
1083TP53H179Y
HIS179TYR,H140Y,H47Y
NC_000017.10:g.7578395G>A,NM_000546.5:c.535C>T,NP_000537.3:p.His179Tyr,ENST00000269305.4:c.535C>Tmissense_variant
1079TP53H193RNC_000017.10:g.7578271T>C,NM_000546.5:c.578A>G,NP_000537.3:p.His193Arg,ENST00000269305.4:c.578A>Gmissense_variant
3768TP53I162F
3764TP53K139E
4111TP53L111R
4114TP53L139N
3771TP53L252F
3801TP53L257P
3775TP53L308M
3776TP53L323P
3580TP53L330P
3581TP53L330R
3583TP53L344P
4452TP53Loss
1066TP53M237I
MET237ILE
ENST00000269305.4:c.711G>Tmissense_variant
3789TP53M246L
222TP53Mutationprotein_altering_variant
3787TP53N239S
1306TP53Overexpression