CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Variants

1951 variants indexed

Variant Types

Sequence Ontology (SO) terms describing the molecular consequence of each variant, as curated in CIViC. Hover a bar for the definition.

CIViC IDGeneVariantHGVSType(s)
3138NPM1MUTATION
87NPM1W288FS
NPM1-A,RS587776806,TRP288FS
NM_002520.6:c.860_863dupTCTG,NC_000005.9:g.170837544_170837547dupTCTG,NP_002511.1:p.Trp288Cysfs,ENST00000517671.1:c.860_863dupTCTGframeshift_elongation
513NPM1::ALKFusion
T(2;5)(P23;Q35),NPM-ALK,NPM1-ALK
transcript_fusion
5011NPM1::MLF1Fusion
NPM1-MLF1
transcript_fusion
401NQO1EXPRESSION
5253NQO1Overexpression
402NQO1P187S
PRO187SER
NM_000903.2:c.559C>T,NP_000894.1:p.Pro187Ser,NC_000016.9:g.69745145G>Amissense_variant
92NRASG12missense_variant
596NRASG12/G13protein_altering_variant
897NRASG12C
RS121913250,GLY12CYS
NM_002524.4:c.34G>T,NP_002515.1:p.Gly12Cys,NC_000001.10:g.115258748C>A,ENST00000369535.4:c.34G>Tmissense_variant
878NRASG12D
RS121913237,GLY12ASP
NM_002524.4:c.35G>A,NP_002515.1:p.Gly12Asp,NC_000001.10:g.115258747C>T,ENST00000369535.4:c.35G>Amissense_variant
93NRASG13D
GLY13ASP,RS121434596
NM_002524.4:c.38G>A,NP_002515.1:p.Gly13Asp,NC_000001.10:g.115258744C>T,ENST00000369535.4:c.38G>Amissense_variant
896NRASG13R
RS121434595,GLY13ARG
NM_002524.4:c.37G>C,NP_002515.1:p.Gly13Arg,NC_000001.10:g.115258745C>G,ENST00000369535.4:c.37G>Cmissense_variant
208NRASMutationgain_of_function_variant,transcript_variant
1654NRASQ179*
Q179X,GLN179TER
ENST00000369535.4:c535C>Tstop_gained
94NRASQ61
GLN61
missense_variant
893NRASQ61H
RS121913255,GLN61HIS
NM_002524.4:c.183A>C,NP_002515.1:p.Gln61His,NC_000001.10:g.115256528T>G,ENST00000369535.4:c.183A>Cmissense_variant
427NRASQ61K
GLN61LYS,RS121913254
NM_002524.4:c.181C>A,NP_002515.1:p.Gln61Lys,NC_000001.10:g.115256530G>T,ENST00000369535.4:c.181C>Amissense_variant
95NRASQ61L
GLN61LEU,RS11554290
NP_002515.1:p.Gln61Leu,NC_000001.10:g.115256529T>A,NM_002524.4:c.182A>T,ENST00000369535.4:c.182A>Tmissense_variant
96NRASQ61R
GLN61ARG,RS11554290
NM_002524.4:c.182A>G,NP_002515.1:p.Gln61Arg,NC_000001.10:g.115256529T>C,ENST00000369535.4:c.182A>Gmissense_variant
2883NRF1::BRAFFusion
NRF1-BRAF
transcript_fusion
314NRG1Expression
240NT5C2D407A
ASP407ALA
NC_000010.10:g.104850745T>G,NM_012229.4:c.1220A>C,NP_036361.1:p.Asp407Ala,ENST00000343289.5:c.1220A>Cmissense_variant
239NT5C2K359Q
LYS359GLN
NC_000010.10:g.104852980T>G,NM_012229.4:c.1075A>C,NP_036361.1:p.Lys359Gln,ENST00000343289.5:c.1075A>Cmissense_variant
2898NT5C2Mutation
2896NT5C2R238W
238NT5C2R367Q
ARG367GLN
NC_000010.10:g.104852955C>Tmissense_variant
2897NT5C2S445Fgain_of_function_variant,missense_variant
290NT5EOverexpression
1280NTRK1Amplificationtranscript_amplification
4510NTRK1F589L
2690NTRK1G595R
4511NTRK1G667C
4302NTRK1G667S
860NTRK1Overexpression
5332NTRK2Amplification
1281NTRK3Amplificationtranscript_amplification
3468NTRK3F617L
2691NTRK3G623Rmissense_variant
4252NTRK3::SCAPERFusion
NTRK3-SCAPER
transcript_fusion
3271NUP153::ABL1Fusion
NUP153-ABL1
transcript_fusion
2660NUP214::ABL1Fusion
NUP214-ABL1
transcript_fusion
2593NUP98::NSD1Fusion
NUP98-NSD1
transcript_fusion
5145NUP98::vFusion
NUP98 Fusion
transcript_fusion
2974OFD1::JAK2Fusion
OFD1-JAK2
transcript_fusion
2350P2RY8::CRLF2Fusion
PAR DELETION,P2RY8-CRLF2
transcript_fusion
532PALB2Biallelic Inactivationloss_of_function_variant
541PALB2L531FS*30
LEU531FS*30
minus_1_frameshift_variant,SNP
2759PALB2Mutation
286PAPSS1::BRAFFusion
T(4;7)(Q24;Q34),PAPSS1-BRAF
transcript_fusion